A synthetic ω-3 PUFA
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Icosabutate

Item No. 19386

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaen-1-yloxy]-butanoic acid
CAS Number
1253909-57-7
Synonyms
  • PRB 01022
  • PRC 4016
Molecular Formula
C24H38O3
Formula Weight
374.6
Purity
≥95%
Formulation (Request formulation change)
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
0.1 M Na2CO3: 1.7 mg/mlDMF: 100 mg/mlDMSO: 100 mg/mlEthanol: miscible
SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CC)C(O)=O
InChi Code
InChI=1S/C24H38O3/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27-23(4-2)24(25)26/h5-6,8-9,11-12,14-15,17-18,23H,3-4,7,10,13,16,19-22H2,1-2H3,(H,25,26)/b6-5-,9-8-,12-11-,15-14-,18-17-
InChi Key
VOGXDRFFBBLZBT-AAQCHOMXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $90

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    1 mg

    $168

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    Product Description

    Icosabutate is a synthetic ω-3 polyunsaturated fatty acid derived from eicosapentaenoic alcohol and 2-bromo butyric acid. It was designed to resist β-oxidation and complex lipid incorporation and increase efficacy in fatty acid-responsive intracellular signaling systems.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bays, H.E., Hallèn, J., Vige, R., et al. Icosabutate for the treatment of very high triglycerides: A placebo-controlled, randomized, double-blind, 12-week clinical trial. J.Clin.Lipidol. 10(1), 181-191 (2016).

    2. Kastelein, J.J.P., Hallén, J., Vige, R., et al. Icosabutate, a structurally engineered fatty acid, improves the cardiovascular risk profile in statin-treated patients with residual hypertriglyceridemia. Cardiology 135(1), 3-12 (2016).