A potent IDO inhibitor
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IDO-IN-1

Item No. 19402

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
CAS Number
914638-30-5
Molecular Formula
C9H7BrFN5O2
Formula Weight
316.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlEthanol:PBS (pH 7.2) (1:30): 0.025 mg/ml
λmax
238, 282 nm
SMILES
FC1=CC=C(/N=C(C2=NON=C2N)\NO)C=C1Br
InChi Code
InChI=1S/C9H7BrFN5O2/c10-5-3-4(1-2-6(5)11)13-9(14-17)7-8(12)16-18-15-7/h1-3,17H,(H2,12,16)(H,13,14)
InChi Key
ORHZJUSHZUCMKR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $90

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    5 mg

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    10 mg

    $696

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    Cayman Chemical
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    Product Description

    IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor that demonstrates IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively.1 It is inactive against tryptophan 2,3-dioxygenase (TOD; IC50 > 10 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yue, E.W., Douty, B., Wayland, B., et al. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J. Med. Chem. 52(23), 7364-7367 (2009).