A β-lactamase inhibitor
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Clavulanate (potassium salt)

Item No. 19456

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monopotassium salt
CAS Number
61177-45-5
Synonyms
  • BRL 14151K
Molecular Formula
C8H8NO5 • K
Formula Weight
237.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
218, 312, 355 nm
SMILES
O=C1C[C@]2([H])N1[C@@H](C([O-])=O)/C(O2)=C/CO.[K+]
InChi Code
InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1
InChi Key
ABVRVIZBZKUTMK-JSYANWSFSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Clavulanate is a β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC50 values range from 12 to 60 nM).1 While it is not an effective antibiotic by itself, clavulanate is commonly used with other antibiotics that would be inactivated by β-lactamases secreted by bacteria. It is often combined with amoxicillin (Item No. 19188) and other penicillin-based antibiotics.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Drawz, S.M., and Bonomo, R.A. Three decades of β-lactamase inhibitors. Clin. Microbiol. Rev. 23(1), 160-201 (2010).

    2. Chang, K.C., Yew, W.W., Tam, C.M., et al. WHO group 5 drugs and difficult multidrug-resistant tuberculosis: A systematic review with cohort analysis and meta-analysis. Antimicrob. Agents Chemother. 57(9), 4097-4104 (2013).

    3. Huang, R.-L., Huang, Y.-L., Ou, J.-C., et al. Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro. Phytother. Res. 17(5), 449-453 (2003).