A macrolide antibiotic
Related Products
Metabolite(s)
279669(E)-Erythromycin A oxime
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Roxithromycin

Item No. 19465

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9E-[O-[(2-methoxyethoxy)methyl]oxime]-erythromycin
CAS Number
80214-83-1
Synonyms
  • RU 965
  • RU 28965
Molecular Formula
C41H76N2O15
Formula Weight
837.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
C[C@@H]([C@]([H])(O[C@@]([H])(C[C@]1(OC)C)O[C@H]([C@@H]1O)C)[C@@H](C)C(O[C@H](CC)[C@@]([C@@H]([C@H]/2C)O)(C)O)=O)[C@@H](O[C@@]([H])([C@@H]3O)O[C@@H](C[C@@H]3N(C)C)C)[C@](C[C@@H](C)C2=N/OCOCCOC)(C)O
InChi Code
InChI=1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+/t2
InChi Key
RXZBMPWDPOLZGW-XMRMVWPWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 g

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    10 g

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    Cayman Chemical
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    Product Description

    Roxithromycin is a macrolide antibiotic.1 It is active against various Gram-positive and Gram-negative bacteria, including five strains each of Staphylococcus and Streptococcus (geometric mean MICs = 0.08 and 0.79 µg/ml, respectively), as well as several strains each of Corynebacterium, Haemophilus, and S. pneumoniae (MIC50s = 0.02, 0.01, and 2.5 µg/ml, respectively). Roxithromycin is protective against infection by strains of S. aureus, S. pyogenes, S. pneumoniae, or L. monocytogenes in mice with 50% protective dose (PD50) values ranging from 23 to 98 mg/kg. Formulations containing roxithromycin have been used in the treatment of bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chantot, J.F., Bryskier, A., and Gasc, J.C. Antibacterial activity of roxithromycin: A laboratory evaluation. J. Antibiot. (Tokyo) 39(5), 660-668 (1986).