A metabolite of TXB2
Related Products
Labeled Version(s)
3825411-dehydro-2,3-dinor Thromboxane B2-d9
Parent Compound(s)
19030Thromboxane B2
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11-dehydro-2,3-dinor Thromboxane B2

Item No. 19510

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[2R-[2α(1E,3S*),3β(Z),4β]]-5-[tetrahydro-4-hydroxy-2-(3-hydroxy-1-octenyl)-6-oxo-2H-pyran-3-yl]-3-pentenoic acid
CAS Number
79250-60-5
Synonyms
  • 11-dehydro-2,3-dinor TXB2
Molecular Formula
C18H28O6
Formula Weight
340.4
Purity
≥98%
Formulation (Request formulation change)
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlEthanol: 100 mg/mlPBS (pH 7.2): 100 µg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)OC(C1)=O
InChi Code
InChI=1S/C18H28O6/c1-2-3-4-7-13(19)10-11-16-14(8-5-6-9-17(21)22)15(20)12-18(23)24-16/h5-6,10-11,13-16,19-20H,2-4,7-9,12H2,1H3,(H,21,22)/b6-5-,11-10+/t13-,14-,15-,16+/m0/s1
InChi Key
PJAAKFHMQLYVGV-YCEKRRLLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 µg

    $49

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    25 µg

    $115

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    50 µg

    $213

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    100 µg

    $376

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    Product Description

    11-dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite of the TXA2 inactive metabolite TXB2 (Item No. 19030).1 It is formed from TXB2 by cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation.1,2 Levels of 11-dehydro-2,3-dinor TXB2 are increased 5.2-fold in a surgery-induced rat model of tendon overuse.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roberts, L.J., II, Sweetman, B.J., and Oates, J.A. Metabolism of thromboxane B2 in Man. Identification of the major urinary metabolite. The Journal of Biological Chemisty 256(16), 8384-8393 (1981).

    2. Westlund, P., Fylling, A.C., Cederlund, E., et al. 11-Hydroxythromboxane B2 dehydrogenase is identical to cytosolic aldehyde dehydrogenase. FEBS Lett. 345(2-3), 99-103 (1994).

    3. Markworth, J.F., Sugg, K.B., Sarver, D.C., et al. Local shifts in inflammatory and resolving lipid mediators in response to tendon overuse. The FASEB Journal 35(6), e21655 (2021).