An internal standard for the quantification of resolvin D3
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Unlabeled Version(s)
13834Resolvin D3
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Resolvin D3-d5

Item No. 19512

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S,5Z,7E,9E,11R,13Z,15E,17S,19Z)-4,11,17-trihydroxydocosa-5,7,9,13,15,19-hexaenoic-21,21,22,22,22-d5 acid
Synonyms
  • RvD3-d5
Molecular Formula
C22H27D5O5
Formula Weight
381.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: unstableEthanol: 50 mg/mlPBS (pH 7.2): 0.05 mg/ml
λmax
240, 262, 273, 283 nm
SMILES
O[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])[2H])/C=C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCC(O)=O
InChi Code
InChI=1S/C22H32O5/c1-2-3-7-12-19(23)14-10-6-11-15-20(24)13-8-4-5-9-16-21(25)17-18-22(26)27/h3-11,13-14,16,19-21,23-25H,2,12,15,17-18H2,1H3,(H,26,27)/b5-4+,7-3-,11-6-,13-8+,14-10+,16-9-/t19-,20-,21+/m0/s1/i1D3,2D2
InChi Key
QBTJOLCUKWLTIC-NGWGEVSUSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 µg

    $224

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    25 µg

    $503

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    Product Description

    Resolvin D3-d5 (RVD3-d5 is intended for use as an internal standard for the quantification of RVD3 (Item No. 13834) by GC- or LC-MS. RVD3 is a DHA-derived product first identified in mouse inflammatory exudates.1 It reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation. In addition to suppressing leukocyte migration, RVD3 enhances macrophage phagocytosis and efferocytosis.2 Unlike other resolvins, RVD3 appears late in resolution in mouse peritonitis.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Serhan, C.N., Hong, S., Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals. J. Exp. Med. 196(8), 1025-1037 (2002).

    2. Dalli, J., Winkler, J.W., Colas, R.A., et al. Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents. Chem. Biol. 20(2), 188-201 (2015).

    3. Serhan, C.N. Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology. Nature 510(7503), 92-101 (2014).

    Product Citations

    Meriwether, D., Sulaiman, D., Volpe, C., et al. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model. J. Clin. Invest. 130, 3670-3685 (2019).