A fungal metabolite with diverse biological activities
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Cyclosporin B

Item No. 19525

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-L-alanine-cyclosporin A
CAS Number
63775-95-1
Synonyms
  • Antibiotic S 7481F2
Molecular Formula
C61H109N11O12
Formula Weight
1188.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 3 mg/mlEthanol: 14 mg/ml
SMILES
O[C@@H]([C@](C(N[C@H](C(N(CC(N(C)[C@H](C(N[C@@H](C(C)C)C(N(C)[C@H]1CC(C)C)=O)=O)CC(C)C)=O)C)=O)C)=O)([H])N(C([C@H](C(C)C)N(C([C@@H](N(C([C@H](CC(C)C)N(C([C@H](NC([C@@H](NC1=O)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)=O)C)[C@H](C)C/C=C/C
InChi Code
InChI=1S/C61H109N11O12/c1-25-26-27-39(14)51(74)50-55(78)64-41(16)56(79)66(18)32-47(73)67(19)43(28-33(2)3)54(77)65-48(37(10)11)60(83)68(20)44(29-34(4)5)53(76)62-40(15)52(75)63-42(17)57(80)69(21)45(30-35(6)7)58(81)70(22)46(31-36(8)9)59(82)71(23)49(38(1
InChi Key
UCOQITKXMNKTKF-MXGZYYNMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $51

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    5 mg

    $152

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    10 mg

    $253

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    25 mg

    $443

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    Product Description

    Cyclosporin B is a minor cyclopeptide metabolite produced by T. polysporum and other deuteromycota with diverse biological activities.1 It inhibits the growth of T lymphoma cells in a concentration-dependent manner.2 Cyclosporin B also inhibits P-glycoprotein (P-gp) activity in vitro with an IC50 value of 4.7 μM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Traber, R., Kuhn, M., Loosli, H.R., et al. New cyclopeptides from Trichoderma polysporum (Link ex Pers.) Rifai: Cyclosporins B, D and E. Helv. Chim. Acta. 60(5), 1568-1578 (1977).

    2. Koponen, M., and Loor, F. Activity of some natural and modified (fluorescent) cyclosporins on T cells. Ann. Immunol. (Paris) 134C(2), 171-189 (1983).

    3. Loor, F., Tiberghien, F., Wenandy, T., et al. Cyclosporins: Structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter. J. Med. Chem. 45(21), 4598-4612 (2002).