A caged neurotransmitter used with photolysis
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Alternative(s)
9004557MNI-caged-L-glutamate
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MNI-caged-L-glutamate (trifluoroacetate salt)

Item No. 19532

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS)-α-amino-2,3-dihydro-4-methoxy-7-nitro-δ-oxo-1H-indole-1-pentanoic acid, 2,2,2-trifluoroacetate
CAS Number
2226362-29-2
Molecular Formula
C14H17N3O6 • CF3COOH
Formula Weight
437.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 0.25 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
213, 249, 304 nm
SMILES
COC1=C2C(N(C(CC[C@H](N)C(O)=O)=O)CC2)=C([N+]([O-])=O)C=C1.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C14H17N3O6.C2HF3O2/c1-23-11-4-3-10(17(21)22)13-8(11)6-7-16(13)12(18)5-2-9(15)14(19)20;3-2(4,5)1(6)7/h3-4,9H,2,5-7,15H2,1H3,(H,19,20);(H,6,7)/t9-;/m0./s1
InChi Key
YHZQLUFSVKYSRH-FVGYRXGTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $280

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    Product Description

    MNI-caged-L-glutamate is a form of glutamate linked to a 4-methoxy-7-nitroindolinyl (MNI) photoprotecting group that is pharmacologically inactive at neuronal glutamate receptors (up to mM concentrations).1 Upon exposure to light (300 - 380 nm excitation), L-glutamate is cleaved of MNI and released within submicroseconds.1 This compound can be used to investigate the mechanisms of fast synaptic glutamate receptors in situ.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Canepari, M., Nelson, L., Papageorgiou, G., et al. Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters. J. Neurosci. Methods 112(1), 29-42 (2001).