A sulfonamide antibiotic
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Sulfamoxole

Item No. 19537

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-N-(4,5-dimethyl-2-oxazolyl)-benzenesulfonamide
CAS Number
729-99-7
Synonyms
  • NSC 683535
Molecular Formula
C11H13N3O3S
Formula Weight
267.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
249, 270 nm
SMILES
NC1=CC=C(S(NC2=NC(C)=C(C)O2)(=O)=O)C=C1
InChi Code
InChI=1S/C11H13N3O3S/c1-7-8(2)17-11(13-7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6H,12H2,1-2H3,(H,13,14)
InChi Key
CYFLXLSBHQBMFT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    250 mg

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    Cayman Chemical
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    Product Description

    Sulfamoxole is a sulfonamide antibiotic.1 It is inactive or weakly active against bacteria when used alone but acts synergistically with trimethoprim (Item No. 16473) against a variety of bacteria in vitro, including strains of S. pyogenes, E. coli, and P. vulgaris when used at concentrations of 1.95-7.8, 0.12-1.95, and 0.48-0.97 µg/ml, respectively. Sulfamoxole, in combination with trimethoprim, is effective in mouse models of E. coli or P. vulgaris infection. It inhibits P. carinii recombinant dihydropteroate synthase (DHPS), an enzyme required for the biosynthesis of folate, with an IC50 value of 0.089 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Böhni, E. Bacteriostatic and bactericidal activity of two trimethoprim-sulfonamide combinations. Chemotherapy 22(3-4), 262-273 (1976).

    2. Hong, Y.-L., Hossler, P.A., Calhoun, D.H., et al. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob. Agents Chemother. 39(8), 1756-1763 (1995).