A stable isomer of 15(S)-HETE
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(5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic Acid

Item No. 19557

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
15R-hydroxy-5Z,11Z-eicosadien-13-ynoic acid
CAS Number
339534-01-9
Synonyms
  • HETE Analog 1
  • Hydroxyeicosatetraenoic Acid Analog 1
Molecular Formula
C20H32O3
Formula Weight
320.5
Purity
≥98%
Formulation (Request formulation change)
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: MiscibleEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
227 nm
SMILES
CCCCC[C@@H](O)C#C/C=C\CCCC/C=C\CCCC(O)=O
InChi Code
InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h8-11,19,21H,2-7,12-13,15-16,18H2,1H3,(H,22,23)/b10-8-,11-9-/t19-/m1/s1
InChi Key
FXVHFLDCTFMIGD-DPTNXLIISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    250 µg

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    Product Description

    (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid is a stable isomer of 15(S)-HETE (Item No. 34720), a major arachidonic acid metabolite from the 15-lipoxygenase pathway.1 (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid elicits concentration-dependent contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of hormone-independent prostate carcinoma PC-3 cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pfister, S.L., Klimko, P.G., and Conrow, R.E. (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid: A stable isomer of 15(S)-HETE that retains key vasoconstrictive and antiproliferative activity. Prostaglandins Other Lipid Mediat. Apr, (2016).