A Smo receptor agonist
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Hh-Ag 1.5

Item No. 19558

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide
CAS Number
612542-14-0
Synonyms
  • SAG1.5
Molecular Formula
C28H26ClF2N3OS
Formula Weight
526.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CN[C@H](CC1)CC[C@@H]1N(C(C2=C(Cl)C3=C(C(F)=CC=C3F)S2)=O)CC4=CC=CC(C5=CC=NC=C5)=C4
InChi Code
InChI=1S/C28H26ClF2N3OS/c1-32-20-5-7-21(8-6-20)34(16-17-3-2-4-19(15-17)18-11-13-33-14-12-18)28(35)27-25(29)24-22(30)9-10-23(31)26(24)36-27/h2-4,9-15,20-21,32H,5-8,16H2,1H3/t20-,21-
InChi Key
RXZDWPYJFCAZCW-MEMLXQNLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $94

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    5 mg

    $422

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    10 mg

    $655

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    Product Description

    Hh-Ag 1.5 is an agonist of smoothened (Smo) receptor.1 It induces nuclear glioma-associated oncogene 1 (Gli1) expression in a reporter assay using NIH3T3 cells (EC50 = 0.39 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rominger, C.M., Bee, W.L.T., Copeland, R.A., et al. Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J. Pharmacol. Exp. Ther. 329(3), 995-1005 (2009).