An XMP aminase-inhibiting antibiotic
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Psicofuranine

Item No. 19574

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1'-C-(hydroxymethyl)-adenosine
CAS Number
1874-54-0
Synonyms
  • Angustmycin C
  • NSC 53104
Molecular Formula
C11H15N5O5
Formula Weight
297.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
OC[C@@H]1[C@@H](O)[C@@H](O)[C@@](N2C=NC3=C2N=CN=C3N)(CO)O1
InChi Code
InChI=1S/C11H15N5O5/c12-9-6-10(14-3-13-9)16(4-15-6)11(2-18)8(20)7(19)5(1-17)21-11/h3-5,7-8,17-20H,1-2H2,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
InChi Key
BNZYRKVSCLSXSJ-IOSLPCCCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $117

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    5 mg

    $456

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    Product Description

    Psicofuranine is an antibiotic and antitumor compound that acts as an inhibitor of xanthosine monophosphate (XMP) aminase (IC50 = 67 µM), causing guanine deficiency in enteric bacteria.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hanka, L.J. Mechanism of action of psicofuranine. J. Bacteriol. 80, 30-36 (1960).

    2. Udaka, S., and Moyed, H.S. Inhibition of parental and mutant xanthosine 5'-phosphate aminases by piscofuranine. The Journal of Biological Chemisty 238, 2797-2803 (1963).

    3. Fukuyama, T.T. Formation of an adenyl xanthosine monophosphate intermediate by xanthosine 5'-phosphate aminase and its inhibition by psicofuranine. The Journal of Biological Chemisty 241(20), 4745-4749 (1966).