A fluorogenic lipase substrate
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4-Methylumbelliferyl Oleate

Item No. 19590

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9Z-octadecenoic acid-4-methyl-2-oxo-2H-1-benzopyran-7-yl ester
CAS Number
18323-58-5
Synonyms
  • 7-hydroxy-4-Methylcoumarin Oleate
  • 4-Methylumbelliferone Oleate
  • 4-MU Oleate
  • 4-MUO
Molecular Formula
C28H40O4
Formula Weight
440.6
Purity
≥98%
Emission
445-454 nm
Excitation
330 (pH 4.6), 370 (pH 7.4), 385 (pH 10.4)
Formulation (Request formulation change)
A low-melting solid
Solubility(Learn about Variance in Solubility)
Chloroform: 20 mg/mlDMF: 10 mg/mlDMSO: 0.1 mg/ml
λmax
274, 312 nm
SMILES
O=C1C=C(C)C2=C(C=C(OC(CCCCCCC/C=C\CCCCCCCC)=O)C=C2)O1
InChi Code
InChI=1S/C28H40O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27(29)31-24-19-20-25-23(2)21-28(30)32-26(25)22-24/h10-11,19-22H,3-9,12-18H2,1-2H3/b11-10-
InChi Key
NKQFKJYKCVDLPT-KHPPLWFESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    Product Description

    4-Methylumbelliferyl (4-MU) oleate is a fluorogenic substrate for acid and alkaline lipases.1,2,3 It is cleaved by lipases, liberating 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Armstrong, M.L., Mathur, S.N., Sando, G.N., et al. Lipid metabolism in xanthomatous skin of hypercholesterolemic rabbits. Am. J. Pathol. 125(2), 339-348 (1986).

    2. Moncla, B.J., and Pryke, K.M. Oleate lipase activity in Gardnerella vaginalis and reconsideration of existing biotype schemes. BMC Microbiol. 9:78, (2009).

    3. Ogawa, A., Kobayashi, T., Sakai, F., et al. Lactobacillus gasseri SBT2055 suppresses fatty acid release through enlargement of fat emulsion size in vitro and promotes fecal fat excretion in healthy Japanese subjects. Lipids Health Dis. 14:20, (2015).

    4. Zhi, H., Wang, J., Wang, S., et al. Fluorescent properties of hymecromone and fluorimetric analysis of hymecromone in compound dantong capsule. J. Spectrosc. 147128 (2013).