A selective PP2A inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cytostatin (sodium salt)

Item No. 19602

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5S,6S)-5,6-dihydro-6-[(1S,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-1,5-dimethyl-4-(phosphonooxy)-7,9,11-tridecatrien-1-yl]-5-methyl-2H-pyran-2-one, monosodium salt
CAS Number
457070-06-3
Molecular Formula
C21H32O7P • Na
Formula Weight
450.4
Purity
≥75%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: SolubleWater: Soluble
SMILES
O=C1O[C@]([C@@H](C)CC[C@H](OP(O)([O-])=O)[C@@H](C)[C@@H](O)/C=C\C=C/C=C/C)([H])[C@@H](C)C=C1.[Na+]
InChi Code
InChI=1S/C21H33O7P.Na/c1-5-6-7-8-9-10-18(22)17(4)19(28-29(24,25)26)13-11-15(2)21-16(3)12-14-20(23)27-21;/h5-10,12,14-19,21-22H,11,13H2,1-4H3,(H2,24,25,26);/q;+1/p-1/b6-5+,8-7-,10-9-;/t15-,16-,17-,18-,19-,21-;/m0./s1
InChi Key
DXWSCXWALSKXSD-IAPNMYKYSA-M
Origin
Bacterium/Streptomyces sp. MJ654-NF4
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    250 µg

    $278

    Add

    1 mg

    $775

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 µg/ml, respectively) and B16 cells metastatic activity in mice.1,2 It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 µg/ml).3 Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Amemiya, M., Ueno, M., Osono, M., et al. Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. (Tokyo) 47(5), 536-540 (1994).

    2. Masuda, T., Watanabe, S.-i., Amemiya, M., et al. Inhibitory effect of cytostatin on spontaneous lung metastases of B16-BL6 melanoma cells. J. Antibiot. (Tokyo) 48(6), 528-529 (1995).

    3. Yamazaki, K., Amemiya, M., Ishizuka, M., et al. Screening for apoptosis inducers in microbial products and induction of apoptosis by cytostatin. J. Antibiot. (Tokyo) 48(10), 1138-1140 (1995).

    4. Kawada, M., Amemiya, M., Ishizuka, M., et al. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Biochim. Biophys. Acta 1452(2), 209-217 (1999).

    5. Swingle, M.R., Amable, L., Lawhorn, B.G., et al. Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and (β12-β13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors. J. Pharmacol. Exp. Ther. 331(1), 45-53 (2009).