An irreversible inhibitor of MALT1
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Z-VRPR-FMK (trifluoroacetate salt)

Item No. 19617

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-L-prolinamide, 2,2,2-trifluoroacetate
Synonyms
  • Z-Val-Arg-Pro-DL-Arg-FMK
Molecular Formula
C31H49FN10O6 • CF3COOH
Formula Weight
790.8
Purity
≥90%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N2CCC[C@H]2C(N[C@H](C(CF)=O)CCCNC(N)=N)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C31H49FN10O6.C2HF3O2/c1-19(2)25(41-31(47)48-18-20-9-4-3-5-10-20)27(45)40-22(12-7-15-38-30(35)36)28(46)42-16-8-13-23(42)26(44)39-21(24(43)17-32)11-6-14-37-29(33)34;3-2(4,5)1(6)7/h3-5,9-10,19,21-23,25H,6-8,11-18H2,1-2H3,(H,39,44)(H,40,45)(H,41
InChi Key
WIPHXOQUHDJLCU-WCFRTMNKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $347

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    1 mg

    $636

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    Product Description

    Z-VRPR-FMK is a selective, irreversible inhibitor of the paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), an endopeptidase that targets BCL10 and reduces NF-κB activation in lymphocytes at 12.5 to 75 µM.1,2,3 Other MALT1 substrates that may be affected by Z-VRPR-FMK are TNFAIP3 and CYLD.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rebeaud, F., Hailfinger, S., Posevitz-Fejfar, A., et al. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat. Immunol. 9(3), 272-281 (2008).

    2. Hachmann, J., Snipas, S.J., van Raam, B.J., et al. Mechanism and specificity of the human paracaspase MALT1. Biochem. J. 443(1), 287-295 (2012).

    3. Fernandez-Jimenez, N., Castellanos-Rubio, A., Plaza-Izurieta, L., et al. Coregulation and modulation of NF.kapa.B-related genes in celiac disease: Uncovered aspects of gut mucosal inflammation. Hum. Mol. Genet. 23(5), 1298-1310 (2014).