A TLR7 agonist
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GS-9620

Item No. 19628

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl]-6(5H)-pteridinone
CAS Number
1228585-88-3
Synonyms
  • Vesatolimod
Molecular Formula
C22H30N6O2
Formula Weight
410.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 15 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
214, 282 nm
SMILES
O=C(NC1=C2N=C(OCCCC)N=C1N)CN2CC3=CC(CN4CCCC4)=CC=C3
InChi Code
InChI=1S/C22H30N6O2/c1-2-3-11-30-22-25-20(23)19-21(26-22)28(15-18(29)24-19)14-17-8-6-7-16(12-17)13-27-9-4-5-10-27/h6-8,12H,2-5,9-11,13-15H2,1H3,(H,24,29)(H2,23,25,26)
InChi Key
VFOKSTCIRGDTBR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    100 mg

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    Cayman Chemical
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    Product Description

    GS-9620 is an orally available agonist of toll-like receptor 7 (TLR7; EC50 = 291 nM) with 30-fold selectivity over TLR8 (EC50 = 9 µM).1 It has been shown to stimulate a TLR7 immune response in two different animal models of chronic hepatitis B infection and to inhibit HIV-1 infection in human peripheral blood mononuclear cells.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Turnas, P., Zheng, X., Lu, B., et al. Preclinical characterization of GS-9620, a potent and selective oral TLR7 agonist. J. Hepatol. 54, S446-S447 (2011).

    2. Menne, S., Tumas, D.B., Liu, K.H., et al. Sustained efficacy and seroconversion with the toll-like receptor 7 agonist GS-9620 in the woodchuck model of chronic hepatitis B. J. Hepatol. 62(6), 1237-1245 (2015).

    3. Lanford, R.E., Guerra, B., Chavez, D., et al. GS-9620, an oral agonist of toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology 144(7), 1508-1517 (2013).

    4. Bam, R.A., Hansen, D., Irrinki, A., et al. TLR7 agonist GS-9620 is a potent inhibitor of acute HIV-1 infection in human peripheral blood mononuclear cells. Antimicrob. Agents Chemother. [Epub ahead of print], 1-42 (2016).