A metabolite of cholestane-3β,5α,6β-triol
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3β,5α,6β-Trihydroxycholanic Acid

Item No. 19636

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β,5α,6β-trihydroxy-cholan-24-oic acid
CAS Number
16030-92-5
Molecular Formula
C24H40O5
Formula Weight
408.6
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
OC(CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])C[C@@H](O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=O
InChi Code
InChI=1S/C24H40O5/c1-14(4-7-21(27)28)17-5-6-18-16-12-20(26)24(29)13-15(25)8-11-23(24,3)19(16)9-10-22(17,18)2/h14-20,25-26,29H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16+,17-,18+,19+,20-,22-,23-,24+/m1/s1
InChi Key
NMKAZCXSXYNCFW-DWQVTILUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    3β,5α,6β-Trihydroxycholanic acid is a metabolite of 5α,6β-dihydroxycholestanol (Item No. 25538).1,2 It is increased in dried blood spots from patients with Niemann-Pick disease type C, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kikuchi, S., Imai, Y., Suzuoki, Z., et al. Biologic studies of cholestane-3β,5α,6β-triol and its derivatives. III. The metabolic fate and metabolites of cholestane-3β,5α,6β-triol in animals. J. Pharmacol. Exp. Ther. 159(2), 399-408 (1968).

    2. Jiang, X., Sidhu, R.S., Mydock-McGrane, L., et al. Development of a bile acid-based newborn screen for Niemann-Pick disease type C. Sci. Transl. Med. 8(337), 337ra363 (2016).