NE 100

NE 100 is a potent antagonist of sigma-1 (σ₁) receptors (IC₅₀ = 4.16 nM).^1,2,3 It only weakly antagonizes dopamine, serotonin, and PCP receptors, but may indirectly alter receptor activity through its effects on σ₁.^1,2,3 NE 100 is commonly used to study the role of σ₁ receptor signaling in cells or animals.^4,5

WARNING This product is not for human or veterinary use.

1. Chaki, S., Tanaka, M., Muramatsu, M., et al. NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain. Eur. J. Pharmacol. 251(1), R1-2 (1994).

2. Okuyama, S., Imagawa, Y., Ogawa, S., et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 53(18), PL285-PL290 (1993).

3. Yamamoto, H., Yamamoto, T., Sagi, N., et al. NE-100, a novel sigma ligand: Effects on [³H]TCP binding to intact primary cultured neuronal cells. Life Sci. 56(2), PL39-PL43 (1995).

4. Dalwadi, D.A., Kim, S., and Schetz, J.A. Activation of the sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astroglia. Neurochem Int. 105(5), 27-31 (2017).

5. Hong, J., Sha, S., Zhou, L., et al. Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons. Cell Death Dis. 6, e1832 (2015).