A natural exportin 1 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

D,L-1′-Acetoxychavicol Acetate

Item No. 19649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(acetyloxy)-α-ethenyl-benzenemethanol, acetate
CAS Number
53890-21-4
Synonyms
  • ACA
  • 1'-Acetoxychavicol Acetate
  • Galangal Acetate
Molecular Formula
C13H14O4
Formula Weight
234.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mLDMSO: 20 mg/mLEthanol: 20 mg/mLEthanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
λmax
218 nm
SMILES
CC(OC1=CC=C(C(OC(C)=O)C=C)C=C1)=O
InChi Code
InChI=1S/C13H14O4/c1-4-13(17-10(3)15)11-5-7-12(8-6-11)16-9(2)14/h4-8,13H,1H2,2-3H3
InChi Key
JAMQIUWGGBSIKZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $41

    Add

    5 mg

    $167

    Add

    10 mg

    $312

    Add

    25 mg

    $728

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    D,L-1′-Acetoxychavicol acetate is a natural compound first isolated from the rhizomes of ginger-like plants. It has a wide array of cellular effects that may be largely explained by its ability to inhibit exportin 1 and prevent the export of proteins from the nucleus.1,2 In this way, D,L-1′-acetoxychavicol acetate reduces several intracellular signaling pathways, including NF-κB, impacting inflammation, cancer, viral replication, and other processes.3,2,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tamura, S., Shiomi, A., Kaneko, M., et al. New rev-export inhibitor from Alpinia galanga and structure-activity relationship. Bioorg. Med. Chem. Lett. 19(9), 2555-2557 (2009).

    2. Turner, J.G., Dawson, J., and Sullivan, D.M. Nuclear export of proteins and drug resistance in cancer. Biochem. Pharmacol. 83(8), 1021-1032 (2012).

    3. Murakami, A., and Ohigashi, H. Targeting NOX, INOS and COX-2 in inflammatory cells: Chemoprevention using food phytochemicals. Int. J. Cancer 121(11), 2357-2363 (2007).

    4. Watanabe, K., Takatsuki, H., Sonoda, M., et al. Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and Alpinia galanga. Drug Discov. Ther. 5(1), 26-31 (2016).