An enterotoxin
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Cholera Toxin (azide free)

Item No. 19654

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Choleragen
  • CT
Purity
≥95% (estimated by SDS-PAGE)
Formulation (Request formulation change)
Each vial contains 1 mg of lyophilized cholera toxin (CT). When reconstituted to 0.5 ml with water, the buffer is 0.05 M Tris, 0.2 M sodium chloride, 0.001 M disodium EDTA at pH 7.5
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $373

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    Product Description

    Cholera toxin is produced by V. cholerae and is a multimeric enterotoxin that consists of a single A subunit surrounded by five B subunits.1 Following binding to the membrane of enteric cells, the toxin is endocytosed and travels to the endoplasmic reticulum where the enzymatically active A subunit (CTA1) is translocated to the cytosol. Within the cytosol, CTA1 catalyzes the ADP-ribosylation of the Gsα protein, which activates adenylate cyclase, locking it in an ‘on’ position.2 The increased intracellular concentration of cAMP causes hypersecretion of chloride and bicarbonate ions, which results in increased fluid secretion and severe diarrhea characteristic of the disease cholera.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cho, J.A., Chinnapen, D.J.F., Amar, E., et al. Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins. Front. Cell. Infect. Microbiol. 2(51), (2012).

    2. van Heyningen, S., and King, C.A. Short communications. Subunit A from cholera toxin is an activator of adenylate cyclase in pigeon erythrocytes. Biochem J. 146(1), 269-271 (1975).