TLR4 agonist
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LPS from Escherichia coli O55:B5

Item No. 19660

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formulation (Request formulation change)
Each vial contains LPS isolated from Escherichia coli O55:B5, which was in water when lyophilized
Shipping & Storage Information
Storage
2°C to 8°C
Shipping
Wet ice in continental US; may vary elsewhere
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    2.5 mg

    $351

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    Product Description

    LPS from Escherichia coli O55:B5 is a form of lipopolysaccharide (LPS) extracted from wild-type S-form E. coli serotype O55:B5. It is commonly used to activate toll-like receptor 4 (TLR4) on leukocytes, eliciting inflammatory signaling in isolated cells and in vivo.1,2,3,4 This form of LPS includes three regions, the O-antigenic polysaccharide chain, the core oligosaccharide, and lipid A.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brauer, R.B., Gegenfurtner, C., Neumann, B., et al. Endotoxin-induced lung inflammation is independent of the complement membrane attack complex. Infect. Immun. 68(3), 1626-1632 (2000).

    2. Jungi, T.W., Sager, H., Adler, H., et al. Serum factors, cell membrane CD14, and β2 integrins are not required for activation of bovine macrophages by lipopolysaccharide. Infect. Immun. 65(9), 3577-3584 (1997).

    3. Li, C.C., Munitic, I., Mittelstadt, P.R., et al. Suppression of dendritic cell-derived IL-12 by endogenous glucocorticoids is protective in LPS-induced sepsis. PLoS Biol. 13(10), (2015).

    4. Migale, R., Herbert, B.R., Lee, Y.S., et al. Specific lipopolysaccharide serotypes induce differential maternal and neonatal inflammatory responses in a murine model of preterm labor. Am. J. Pathol. 185(9), 2390-2401 (2015).