TLR4 agonist
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LPS from Escherichia coli O111:B4

Item No. 19661

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formulation (Request formulation change)
Each vial contains LPS isolated from Escherichia coli O111:B4, which was in water when lyophilized
Solubility(Learn about Variance in Solubility)
Water: 5 mg/ml (slightly hazy)
Shipping & Storage Information
Storage
2°C to 8°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $341

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    Product Description

    LPS from Escherichia coli O111:B4 is a form of lipopolysaccharide (LPS) extracted from wild-type S-form E. coli serotype O111:B4. It is commonly used to activate Toll-like receptor 4 (TLR4) on leukocytes, eliciting inflammatory signaling in isolated cells and in vivo.1,2,3,4 This form of LPS includes three regions, the O-antigenic polysaccharide chain, the core oligosaccharide, and lipid A.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mai, K., Chui, J.J., Di Girolamo, N., et al. Role of toll-like receptors in human iris pigment epithelial cells and their response to pathogen-associated molecular patterns. J. Inflamm. (Lond.) 11, 20 (2014).

    2. Medearis, D.N., Camitta, B.M., and Heath, E.C. Cell wall composition and virulence in Escherichia coli. J. Exp. Med. 128(3), 399-414 (1968).

    3. Migale, R., Herbert, B.R., Lee, Y.S., et al. Specific lipopolysaccharide serotypes induce differential maternal and neonatal inflammatory responses in a murine model of preterm labor. Am. J. Pathol. 185(9), 2390-2401 (2015).

    4. Pirianov, G., MacIntyre, D.A., Lee, Y., et al. Specific inhibition of c-Jun N-terminal kinase delays preterm labour and reduces mortality. Reproduction 150(4), 269-277 (2015).