A bacterial toxin
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Toxin A from Clostridium difficile

Item No. 19664

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • TcdA
Purity
≥80% (estimated by SDS-PAGE)
Formulation (Request formulation change)
100 µg of C. difficile toxin A enterotoxin; when reconsituted with 0.5 ml of water, the buffer contains 50 mM Tris, 50 mM sodium chloride, pH 7.5, and 0.1% trahalose
Solubility(Learn about Variance in Solubility)
Water: soluble
UniProt Accession №
P16154
Shipping & Storage Information
Storage
4°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $1,022

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    Cayman Chemical
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    Product Description

    Toxin A from Clostridium difficile, also known as TcdA, is an enterotoxin that has glucosyltransferase and cysteine protease activities. It inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion.1,2 Toxin A can induce activation of the inflammasome and apoptosis.3 While both toxin A and toxin B (Item No. 19665) inactivate Rho family GTPases, toxin A has a higher binding affinity for epithelial cell surface carbohydrates.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, S., Sun, C., Wang, H., et al. The role of rho GTPases in toxicity of Clostridium difficile toxins. Toxins (Basel) 7(12), 5254-5267 (2016).

    2. Pruitt, R.N., and Lacy, D.B. Toward a structural understanding of Clostridium difficile toxins A and B. Front. Cell. Infect. Microbiol. 2, 28 (2012).

    3. Di Bella, S., Ascenzi, P., Siarakas, S., et al. Clostridium difficile toxins A and B: Insights into pathogenic properties and extraintestinal effects. Toxins (Basel) 8(5), (2016).