A reduced form of coenzyme Q10
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Ubiquinol

Item No. 19677

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[3,7,11,15,19,23,27,31,35,39-decamethyl-2E,6E,10E,14E,18E,22E,26E,30E,34E,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl-1,4-benzenediol
CAS Number
992-78-9
Synonyms
  • Dihydro Coenzyme Q10
  • Reduced Coenzyme Q10
Molecular Formula
C59H92O4
Formula Weight
865.4
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
COC1=C(OC)C(O)=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)\C)C(C)=C1O
InChi Code
InChI=1S/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,2
InChi Key
QNTNKSLOFHEFPK-FPXYFCFXSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $145

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    1 mg

    $260

    Add

    5 mg

    $1,082

    Add
    Product Description

    Ubiquinol is a reduced form of coenzyme Q10 (CoQ10; Item No. 11506), which exists in three redox states: fully oxidized (CoQ10/ubiquinone), partially reduced (semiquinone/ubisemiquinone), and fully reduced (ubiquinol).1 CoQ10 acts as an electron shuttle in the electron transport chain via its reduction to ubiquinol between mitochondrial complexes I and II, also known as NADH dehydrogenase and succinate dehydrogenase, respectively, and mitochondrial complex III, also known as cytochrome bc1 complex.2,3 CoQ10 is also reduced to ubiquinol by ferroptosis suppressor protein 1 (FSP1) with NADPH as a cofactor, and ubiquinol traps lipid peroxyl radicals and inhibits lipid peroxidation helping to prevent ferroptosis.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ernster, L., and Dallner, G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim. Biophys. Acta 1271(1), 195-204 (1995).

    2. Crane, F.L. Biochemical functions of coenzyme Q10. J. Am. Coll. Nutr. 20(6), 591-598 (2001).

    3. Acosta, M.J., Fonseca, L.V., Desbats, M.A., et al. Coenzyme Q biosynthesis in health and disease. Biochim. Biophys. Acta 1857(8), 1079-1085 (2016).

    4. Doll, S., Freitas, F.P., Shah, R., et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575(7784), 693-698 (2019).