An LSD1 inhibitor
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Bizine

Item No. 19705

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(2-hydrazinylethyl)phenyl]-benzenebutanamide
CAS Number
1591932-50-1
Molecular Formula
C18H23N3O
Formula Weight
297.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
λmax
246 nm
SMILES
NNCCC(C=C1)=CC=C1NC(CCCC2=CC=CC=C2)=O
InChi Code
InChI=1S/C18H23N3O/c19-20-14-13-16-9-11-17(12-10-16)21-18(22)8-4-7-15-5-2-1-3-6-15/h1-3,5-6,9-12,20H,4,7-8,13-14,19H2,(H,21,22)
InChi Key
NTJQPAASNHXPGP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $132

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    10 mg

    $207

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    Cayman Chemical
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    Product Description

    Bizine is a phenelzine analog that inhibits lysine-specific demethylase 1 (LSD1; Ki(inact) = 59 nM).1 It is 23-fold, 63-fold, and >100-fold selective for LSD-1 over monoamine oxidase (MAO) A, MAOB, and LSD2, respectively.1 Bizine has been shown to induce bulk histone H3 lysine 4 dimethylation in LNCaP cancer cells (EC50 = ~2 µM) and, at 0.5 µM, to protect neurons exposed to oxidative stress.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Prusevich, P., Kalin, J.H., Ming, S.A., et al. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol. 9, 1284-1293 (2014).