A fluorescent membrane probe
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Laurdan

Item No. 19706

Technical Information
Formal Name
1-[6-(dimethylamino)-2-naphthalenyl]-1-dodecanone
CAS Number
74515-25-6
Molecular Formula
C24H35NO
Formula Weight
Purity
≥98%
A crystalline solid
Chloroform: 10 mg/ml
λmax
230, 250, 259, 284, 362 nm
SMILES
CN(C)C1=CC=C2C(C=CC(C(CCCCCCCCCCC)=O)=C2)=C1
InChi Code
InChI=1S/C24H35NO/c1-4-5-6-7-8-9-10-11-12-13-24(26)22-15-14-21-19-23(25(2)3)17-16-20(21)18-22/h14-19H,4-13H2,1-3H3
InChi Key
JHDGGIDITFLRJY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Laurdan is a membrane-permeable fluorescent probe that displays spectral sensitivity to the phospholipid phase of the cell membrane to which it is bound.1 Quantitation of generalized polarization (GP) of laurdan can be used to identify phospholipid phase. When excited at 340 nm, GP values are 0.6 and -0.2 for gel phase and liquid crystalline phase, respectively. GP does not change with polar head group or pH (in the range 4-10); it changes only with phase state.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Parasassi, T., De Stasio, G., Ravagnan, G., et alQuantitation of lipid phases in phospholipid vesicles by the generalized polarization of Laurdan fluorescence. Biophys. J. 60(1), 179-189 (1991).