A negative control for NCT-502 and NCT-503
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PHGDH-inactive

Item No. 19717

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4,6-dimethyl-2-pyridinyl)-4-(4-pyridinyl)-1-piperazinecarbothioamide
CAS Number
1914971-16-6
Synonyms
  • 3-Phosphoglycerate Dehydrogenase-inactive
Molecular Formula
C17H21N5S
Formula Weight
327.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mLDMSO: 5 mg/mLDMSO:PBS (pH 7.2)(1:5): 0.1 mg/mL
λmax
278, 351 nm
SMILES
S=C(N1CCN(C2=CC=NC=C2)CC1)NC3=NC(C)=CC(C)=C3
InChi Code
InChI=1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23)
InChi Key
ITLPIAAGIQAGRA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Product Description

    PHGDH-inactive is an inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 (Item No. 19716) and NCT-503 (Item No. 19718).1 Unlike the inhibitors, PHGDH-inactive does not inhibit PHGDH in vitro (IC50s = >57, 3.7, and 2.5 µM for PHGDH-inactive, NCT-502, and NCT-503, respectively), block serine synthesis in cells, or kill PHGDH-dependent cell lines.1 PHGDH-inactive is intended to serve as a negative control for NCT-502 and NCT-503.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pacold, M.E., Brimacombe, K.R., Chan, S.H., et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat. Chem. Biol. 12(6), 452-458 (2016).