A SHP-1 and PTP1B inhibitor
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PTP Inhibitor I

Item No. 19766

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-bromo-1-(4-hydroxyphenyl)-ethanone
CAS Number
2491-38-5
Synonyms
  • α-Bromo-4-hydroxyacetophenone
  • 2-Bromo-4'-hydroxyacetophenone
  • 4-Hydroxyphenacyl bromide
  • Protein Tyrosine Phosphatase Inhibitor I
  • SHP-1 Inhibitor II
Molecular Formula
C8H7BrO2
Formula Weight
215.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMSO: 20 mg/mLEthanol: 20 mg/mLEthanol:PBS (pH 7.2) (1:10): 0.09 mg/mL
λmax
226, 290 nm
SMILES
OC1=CC=C(C(CBr)=O)C=C1
InChi Code
InChI=1S/C8H7BrO2/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4,10H,5H2
InChi Key
LJYOFQHKEWTQRH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $29

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    100 mg

    $35

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    Product Description

    PTP inhibitor I is an inhibitor of Src homology region 2 domain-containing phosphatase 1 (SHP-1) and protein tyrosine phosphatase 1B (PTP1B; Kis = 43 and 42 µM for the SHP-1 catalytic domain and full-length PTP1B, respectively).1 It inhibits endothelial cell network formation of human umbilical vein endothelial cells (HUVECs) cultured with normal human dermal fibroblasts (IC50 = 3.7 µM).2 PTP inhibitor I has been used in the synthesis of compounds with antibacterial, antifungal, fungicidal, and anticancer activities.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arabaci, G., Guo, X.-C., Beebe, K.D., et al. α-Haloacetophenone derivatives as photoreversible covalent inhibitors of protein tyrosine phosphatases. J. Am. Chem. Soc. 121(21), 5085-5086 (1999).

    2. Sylvest, L., Bendiksen, C.D., and Houen, G. Phosphatase inhibitors with anti-angiogenic effect in vitro. APMIS 118(1), 49-59 (2009).

    3. Prasad, Y.R., Kumar, G.V.S., and Chandrashekar, S.M. Synthesis and biological evaluation of novel 4,5-dihydropyrazole derivatives as potent anticancer and antimicrobial agents. Med. Chem. Res. 22, 2061-2078 (2013).