A fluorescent probe that tags proteins in cells
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ReAsH-EDT2

Item No. 19767

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,6-bis(1,3,2-dithiarsolan-2-yl)-7-hydroxy-3H-phenoxazin-3-one
CAS Number
438226-89-2
Synonyms
  • Lumio Red
Molecular Formula
C16H13As2NO3S4
Formula Weight
545.4
Purity
≥95%
Emission
608 nm
Excitation
593 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleDMSO: 1 mM
SMILES
O=C1C=CC2=NC3=CC=C(O)C([As]4SCCS4)=C3OC2=C1[As]5SCCS5
InChi Code
InChI=1S/C16H13As2NO3S4/c20-11-3-1-9-15(13(11)17-23-5-6-24-17)22-16-10(19-9)2-4-12(21)14(16)18-25-7-8-26-18/h1-4,20H,5-8H2
InChi Key
UNIBJWQHKWCMGJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    250 µg

    $688

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    Product Description

    ReAsH-EDT2 is a fluorescent, membrane-permeable biarsenical compound that binds covalently to tetracysteine sequences, which are engineered into target proteins.1 It binds proteins that have the tetracysteine tag almost immediately after translation.1 ReAsH-EDT2 is commonly used to study protein trafficking, folding, and interactions in living cells or cell lysates.1,2,3 This red-emitting fluorophore is excited at 593 nm, with emission at 608 nm.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rudner, L., Nydegger, S., Coren.L.V., et al. Dynamic fluorescent imaging of human immunodeficiency virus type 1 gag in live cells by biarsenical labeling. J. Virol. 79(7), 4055-4065 (2005).

    2. Luedtke, N.W., Dexter, R.J., Fried, D.B., et al. Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH. Nat. Chem. Biol. 3(12), 779-784 (2007).

    3. Perdios, L., Bunney.T.D., Warren, S.C., et al. Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1. Adv. Biol. Regul. 60, 6-13 (2016).