An atypical antipsychotic
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Analytical Standard(s)
44822Melperone (hydrochloride) (CRM)
Labeled Version(s)
31489Melperone-d4 (hydrochloride)
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Melperone (hydrochloride)

Item No. 19770

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone, monohydrochloride
CAS Number
1622-79-3
Synonyms
  • FG 5111
  • Methylperone
Molecular Formula
C16H22FNO • HCl
Formula Weight
299.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 20 mg/mLEthanol: 20 mg/mLPBS (pH 7.2): 2 mg/mL
λmax
245, 337 nm
SMILES
FC1=CC=C(C(CCCN2CCC(C)CC2)=O)C=C1.Cl
InChi Code
InChI=1S/C16H22FNO.ClH/c1-13-8-11-18(12-9-13)10-2-3-16(19)14-4-6-15(17)7-5-14;/h4-7,13H,2-3,8-12H2,1H3;1H
InChi Key
MQHYXXIJLKFQGY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $41

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    10 mg

    $72

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    25 mg

    $128

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    50 mg

    $196

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    Product Description

    Melperone is an atypical antipsychotic.1 It binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Richelson, E., and Souder, T. Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compounds. Life Sci. 68(1), 29-39 (2000).

    2. Ichikawa, J., and Meltzer, H.Y. The effect of chronic atypical antipsychotic drugs and haloperidol on amphetamine-induced dopamine release in vivo. Brain Res. 574(1-2), 98-104 (1992).