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BMN 673

Item № 19782
CAS № 1207456-01-6
Purity ≥98%
product image
                (CAS 1207456-01-6)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $55.00 0.00
     5 mg $234.00 0.00
     10 mg $413.00 0.00
     25 mg $756.00 0.00

Pricing updated 2019-04-24. Prices are subject to change without notice.

Description
Synonyms
  • Talazoparib

BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of 0.57 nM.1 It similarly binds to PARP1 and PARP2 with Ki values of 1.2 and 0.85 nM, respectively, but has no effect on PARG.1 BMN 673 selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits antitumor activity in xenografted tumors in mice.1

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Technical Information
Formal Name
(8S,9R)-5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one
CAS Number
1207456-01-6
Synonyms
  • Talazoparib
Molecular Formula
C19H14F2N6O
Formula Weight
380.4
Purity
≥98%
Formulation
A crystalline solid
λmax
255, 309 nm
SMILES
O=C1NN=C2[C@H](C3=NC=NN3C)[C@@H](C4=CC=C(F)C=C4)NC5=C2C1=CC(F)=C5
InChI Code
InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1
InChI Key
HWGQMRYQVZSGDQ-HZPDHXFCSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Shen, Y., Rehman, F.L., Feng, Y., et al. BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency Clin.Cancer.Res 19(18), 5003-5015 (2013).

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