A PARP inhibitor
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BMN 673

Item No. 19782

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(8S,9R)-5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one
CAS Number
1207456-01-6
Synonyms
  • Talazoparib
Molecular Formula
C19H14F2N6O
Formula Weight
380.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 20 mg/mlEthanol: 0.25 mg/ml
λmax
255, 309 nm
SMILES
O=C1NN=C2[C@H](C3=NC=NN3C)[C@@H](C4=CC=C(F)C=C4)NC5=C2C1=CC(F)=C5
InChi Code
InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1
InChi Key
HWGQMRYQVZSGDQ-HZPDHXFCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $80

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    5 mg

    $332

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    10 mg

    $583

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    25 mg

    $1,065

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    Cayman Chemical
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    Product Description

    BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of 0.57 nM.1 It similarly binds to PARP1 and PARP2 with Ki values of 1.2 and 0.85 nM, respectively, but has no effect on PARG.1 BMN 673 selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits antitumor activity in xenografted tumors in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shen, Y., Rehman, F.L., Feng, Y., et al. BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency. Clin. Cancer Res. 19(18), 5003-5015 (2013).