A selective inhibitor of Kv2.1 channels
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Product Categories

Product Type

Small Molecule Modulators
Ion Channel Modulators
Blockers

Research Area

RY785

Item No. 19813

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methoxy-α-methyl-N-[2-(4-thiazolyl)-1H-benzimidazol-6-yl]-benzenepropanamide
CAS Number
1393748-80-5
Molecular Formula
C21H20N4O2S
Formula Weight
392.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 15 mg/mlEthanol: 15 mg/ml
λmax
210, 245, 317 nm
SMILES
COC1=CC=CC(CC(C(NC2=CC(N=C(C3=CSC=N3)N4)=C4C=C2)=O)C)=C1
InChi Code
InChI=1S/C21H20N4O2S/c1-13(8-14-4-3-5-16(9-14)27-2)21(26)23-15-6-7-17-18(10-15)25-20(24-17)19-11-28-12-22-19/h3-7,9-13H,8H2,1-2H3,(H,23,26)(H,24,25)
InChi Key
BRHVBJUDTWQELF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $43

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    1 mg

    $81

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    5 mg

    $333

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    10 mg

    $580

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    Product Description

    RY785 is a selective inhibitor of Kv2.1 voltage-gated potassium channels (IC50 = 0.05 µM) that does not affect Cav2 calcium channels.1 It displays over 100-fold selectivity for Kv2.1 over Cav1.2 (IC50 = 17 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Herrington, J., Solly, K., Ratliff, K.S., et al. Identification of novel and selective Kv2 channel inhibitors. Mol. Pharmacol. 80(6), 959-964 (2011).