An affinity probe for amyloid-β
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CRANAD 2

Item No. 19814

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(T-4)-[(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoro-boron
CAS Number
1193447-34-5
Molecular Formula
C23H25BF2N2O2
Formula Weight
410.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
595 nm
SMILES
[F-][B+3]1([F-])[O]=C([CH-]C(/C=C/C2=CC=C(N(C)C)C=C2)=[O]1)/C=C/C3=CC=C(N(C)C)C=C3
InChi Code
InChI=1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3/b15-9+,16-10+
InChi Key
PVXQJYXODFZTBR-KAVGSWPWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    CRANAD 2 is a curcumin derivative and non-conjugated affinity probe for the detection of amyloid-β (Aβ) deposits in vitro and in vivo.1,2 It has high affinity for Aβ (Kd = 38 nM) and, when bound to Aβ aggregates, it exhibits a 70-fold increase in fluorescence intensity, a blue shift from 805 to 715 nm, and a large increase in quantum yield.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ran, C., Xu, X., Raymond, S.B., et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-β deposits. J. Am. Chem. Soc. 131(42), 15257-15261 (2009).

    2. Ran, C., Zhao, W., Moir, R.D., et al. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One 6(4), e19362 (2011).