A fluorescent affinity probe for amyloid-β
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CRANAD 28

Item No. 19816

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
1623747-97-6
Molecular Formula
C27H23BF2N4O2
Formula Weight
484.3
Purity
≥98%
Emission
578 nm
Excitation
498 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
245, 479 nm
SMILES
[F-][B+3]1([F-])[O]=C([CH-]C(/C=C/C2=C(C)N(C3=CC=CC=C3)N=C2)=[O]1)/C=C/C4=C(C)N(C5=CC=CC=C5)N=C4
InChi Code
InChI=1S/C27H23BF2N4O2/c1-20-22(18-31-33(20)24-9-5-3-6-10-24)13-15-26-17-27(36-28(29,30)35-26)16-14-23-19-32-34(21(23)2)25-11-7-4-8-12-25/h3-19H,1-2H3/b15-13+,16-14+
InChi Key
DDFFGVTUEQJYQK-WXUKJITCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $36

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    1 mg

    $68

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    5 mg

    $268

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    10 mg

    $469

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    Product Description

    CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively.1 It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, X., Tian, Y., Yuan, P., et al. A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer’s disease. Chem. Commun. (Camb.) 50(78), 11550-11553 (2014).