An Mcl-1 inhibiting molecule
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MIM1

Item No. 19832

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-1,2,3-benzenetriol
CAS Number
509102-00-5
Molecular Formula
C17H21N3O3S
Formula Weight
347.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:6): 0.14 mg/mlDMSO: 20 mg/mlEthanol: 0.12 mg/ml
λmax
210, 221, 261, 367 nm
SMILES
OC1=CC=C(/C=N/N2/C(SC=C2C)=N/C3CCCCC3)C(O)=C1O
InChi Code
InChI=1S/C17H21N3O3S/c1-11-10-24-17(19-13-5-3-2-4-6-13)20(11)18-9-12-7-8-14(21)16(23)15(12)22/h7-10,13,21-23H,2-6H2,1H3/b18-9+,19-17-
InChi Key
RGGFUBMUOVFZEF-LDRVEFRDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $169

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    Cayman Chemical
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    Product Description

    MIM1 is an inhibitor of Mcl-1, an antiapoptotic Bcl-2 family protein with a role in cancer. It selectively engages the canonical groove of Mcl-1, inhibiting its ability to bind BH3 domains (IC50 = 4.7 µM).1 MIM1 induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cohen, N.A., Stewart, M.L., Gavathiotis, E., et al. A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem. Biol. 19(9), 1175-1185 (2012).