A kinetically selective HDAC2 inhibitor
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BRD4884

Item No. 19834

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)tetrahydro-2H-pyran-4-carboxamide
CAS Number
1404559-91-6
Molecular Formula
C18H19FN2O2
Formula Weight
314.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
λmax
211, 276 nm
SMILES
FC1=CC=C(C2=CC=C(N)C(NC(C3CCOCC3)=O)=C2)C=C1
InChi Code
InChI=1S/C18H19FN2O2/c19-15-4-1-12(2-5-15)14-3-6-16(20)17(11-14)21-18(22)13-7-9-23-10-8-13/h1-6,11,13H,7-10,20H2,(H,21,22)
InChi Key
ZFCDNONWGMYBHA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $36

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    1 mg

    $68

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    5 mg

    $268

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    10 mg

    $469

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    Product Description

    BRD4884 is an HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 µM for HDAC1, 2, and 3, respectively.1 It possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min versus 20 min).1 BRD4884 crosses the blood brain barrier and has been evaluated in CK-p25 mice, a mouse model of neurodegeneration.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wagner, F.F., Zhang, Y.-L., Fass, D.M., et al. Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers. Chem. Sci. 6(1), 804-815 (2015).