A kinetically selective HDAC2 inhibitor
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BRD6688

Item No. 19836

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide
CAS Number
1404562-17-9
Molecular Formula
C16H18N4O
Formula Weight
282.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 30 mg/mlEthanol: 2 mg/ml
λmax
315 nm
SMILES
O=C(N1CCCC1)NC2=CC(C3=CC=NC=C3)=CC=C2N
InChi Code
InChI=1S/C16H18N4O/c17-14-4-3-13(12-5-7-18-8-6-12)11-15(14)19-16(21)20-9-1-2-10-20/h3-8,11H,1-2,9-10,17H2,(H,19,21)
InChi Key
YZXBMJVMSBSGMM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $60

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    5 mg

    $255

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    10 mg

    $339

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    Product Description

    BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 µM for HDAC1, 2, and 3, respectively.1 It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1 (381 min versus 65 min).1 BRD6688 crosses the blood brain barrier and has been shown to rescue the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wagner, F.F., Zhang, Y.-L., Fass, D.M., et al. Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers. Chem. Sci. 6(1), 804-815 (2015).