A flavonoid with diverse biological activities
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Baicalin

Item No. 19843

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl-β-D-glucopyranosiduronic acid
CAS Number
21967-41-9
Synonyms
  • Baicalein 7-glucuronide
Molecular Formula
C21H18O11
Formula Weight
446.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
215, 246, 277, 313 nm
SMILES
OC1=C(O)C(C(C=C(C2=CC=CC=C2)O3)=O)=C3C=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O4
InChi Code
InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1
InChi Key
IKIIZLYTISPENI-ZFORQUDYSA-N
Origin
Plant/Radix scutellariae
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

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    Product Description

    Baicalin is a flavonoid that has been found in S. baicalensis and has diverse biological activities.1,2,3,4,5,6 It reduces NETosis induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in DMSO-differentiated HL-60 neutrophil-like cells when used at a concentration of 10 nM.1 In vivo, baicalin (30 and 100 mg/kg) reduces myocardial apoptosis and increases cardiac microvessel levels of endothelial nitric oxide synthase (eNOS) in a rat model of ischemia-reperfusion injury when administered at doses of 30 and 100 mg/kg.2 Baicalin (50 and 80 mg/kg) increases the number of intratumoral CD8+ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model.3 It reduces LPS-induced cortical production of reactive oxygen species (ROS) and levels of IL-1β and TNF-α in a mouse model of neuroinflammation.4 Baicalin decreases body weight, increases the number of rats with regular estrous cycles, and ameliorates follicular development in a mouse model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS).5 It also decreases immobility time in the forced swim test in a mouse model of depression induced by chronic mild stress.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Juanlu, C., Chen, L., Sung, C.-J., et al. Phytochemicals as potential inhibitors of NETosis: Implications for immunothrombosis and chronic disease management. BMC Complement Med. Ther. (2026).

    2. Bai, J., Wang, Q., Qi, J., et al. Promoting effect of baicalin on nitric oxide production in CMECs via activating the PI3K-AKT-eNOS pathway attenuates myocardial ischemia–reperfusion injury. Phytomedicine 63, 153035 (2019).

    3. Ke, M., Zhang, Z., Xu, B., et al. Baicalein and baicalin promote antitumor immunity by suppressing PD-L1 expression in hepatocellular carcinoma cells. Int. Immunopharmacol. 75, 105824 (2019).

    4. Shah, M.-A., Park, D.-J., Kang, J.-B., et al. Baicalin attenuates lipopolysaccharideinduced neuroinflammation in cerebral cortex of mice via inhibiting nuclear factor kappa B (NF-κB) activation. J. Vet. Med. Sci. 81(9), 1359-1367 (2019).

    5. Wang, W., Zheng, J., Cui, N., et al. Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase. J. Ovarian Res. 12(1), 109 (2019).

    6. Lu, Y., Sun, G., Yang, F., et al. Baicalin regulates depression behavior in mice exposed to chronic mild stress via the Rac/LIMK/cofilin pathway. Biomed. Pharmacother. 116, 109054 (2019).