Schisandrin A

Schisandrin A is a lignan that has been found in Schisandra and has diverse biological activities.^1,2,3,4 It binds to adiponectin receptor 2 (IC₅₀ = 3.2 µM).¹ Schisandrin A (10, 20, and 50 µM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-α and apoptosis in primary mouse microglial cells.² It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 µM.³ Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid β (1-42) (Aβ42; Item No. 20574) in a mouse model of Alzheimer’s disease.⁴

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1. Sun, Y., Zang, Z., Zhong, L., et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One 8(5), e63354 (2013).

2. Song, F., Zeng, K., Liao, L., et al. Schizandrin A inhibits microglia-mediated neuroninflammation through inhibiting TRAF6-NF-κB and Jak2-stat3 signaling pathways. PloS One 11(2), (2016).

3. Zhang, Z.-L., Jiang, Q.-C., and Wang, S.-R. Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation. Breast Cancer 25(2), 233-242 (2018).

4. Hu, D., Li, C., Han, N., et al. Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Aβ₁₋₄₂-induced memory impairment in mice. Planta Med. 78(12), 1332-1336 (2012).