A natural isoflavone
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Neobavaisoflavone

Item No. 19852

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-4H-1-benzopyran-4-one
CAS Number
41060-15-5
Molecular Formula
C20H18O4
Formula Weight
322.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMF:PBS (pH 7.2) (1:4): 0.1 mg/mLDMSO: 10 mg/mLEthanol: 1 mg/mL
λmax
249 nm
SMILES
OC1=CC=C(C(C(C2=CC(C/C=C(C)\C)=C(O)C=C2)=CO3)=O)C3=C1
InChi Code
InChI=1S/C20H18O4/c1-12(2)3-4-14-9-13(5-8-18(14)22)17-11-24-19-10-15(21)6-7-16(19)20(17)23/h3,5-11,21-22H,4H2,1-2H3
InChi Key
OBGPEBYHGIUFBN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $36

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    1 mg

    $68

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    5 mg

    $236

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    10 mg

    $336

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    Product Description

    Neobavaisoflavone is a natural isoflavone that was first isolated from seeds of P. corylifolia, which are used in traditional herbal medicine to treat various skin diseases. Neobavaisoflavone has been found to have diverse effects in isolated mammalian cells, including inhibiting DNA polymerase and carboxylesterase 1 (Ki = 5.3 µM).1,2 It also displays antibiotic activity against Gram-negative multidrug resistant bacteria.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, N.J., Woo, S.H., Cassady, J.M., et al. DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. J. Nat. Prod. 61(3), 362-366 (1998).

    2. Sun, D.X., Ge, G.B., Dong, P.P., et al. Inhibition behavior of fructus psoraleae’s ingredients towards human carboxylesterase 1 (hCES1). Xenobiotica 46(6), 503-510 (2016).

    3. Mbaveng, A.T., Sandjo, L.P., Tankeo, S.B., et al. Antibacterial activity of nineteen selected natural products against multi-drug resistant Gram-negative phenotypes. SpringerPlus 4:823, (2015).