Pricing updated 2018-08-17. Prices are subject to change without notice.
Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens.1 Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).2,3,4
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Akhtar, M.K., Kelly, S.L., and Kaderbhai, M.A. Cytochrome b5 modulation of 17α hydroxylase and 17-
2. Sedláček, M., Kořínek, M., Petrovič, M., et al. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission. Physiol. Res. 57(Suppl 3), S49-S57 (2008).
3. Smith, C.C., Gibbs, T.T., and Farb, D.H. Pregnenolone sulfate as a modulator of synaptic plasticity. Psychopharmacology (Berl) 231(17), 3537-3556 (2014).
Thiel, G., Müller, I., and Rössler, O.G. Signal transduction via TRPM3 channels in pancreatic β-