Pregnenolone (CAS 145-13-1) | Cayman Chemical
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Pregnenolone

Item № 19864
CAS № 145-13-1
Purity ≥98%
product image
                (CAS 145-13-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 mg $25.00 0.00
     1 g $32.00 0.00
     5 g $45.00 0.00
     10 g $75.00 0.00

Pricing updated 2018-05-26. Prices are subject to change without notice.

Description
Synonyms
  • NSC 1616
  • NSC 18158
  • 3β-hydroxy-5-Pregnen-20-one
  • Δ5-Pregnenolone

Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens.1 Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).2,3,4

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Technical Information
Formal Name
3β-hydroxy-pregn-5-en-20-one
CAS Number
145-13-1
Synonyms
  • NSC 1616
  • NSC 18158
  • 3β-hydroxy-5-Pregnen-20-one
  • Δ5-Pregnenolone
Molecular Formula
C21H32O2
Formula Weight
316.5
Purity
≥98%
Formulation
A crystalline solid
SMILES
O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O
InChI Code
InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
InChI Key
ORNBQBCIOKFOEO-QGVNFLHTSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
Room temperature
Shipping
Ambient in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Akhtar, M.K., Kelly, S.L., and Kaderbhai, M.A. Cytochrome b5 modulation of 17α hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis. J. Endocrinol. 187(2), 267-274 (2005).

2. Sedláček, M., Kořínek, M., Petrovič, M., et al. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission. Physiol. Res. 57(Suppl 3), S49-S57 (2008).

3. Smith, C.C., Gibbs, T.T., and Farb, D.H. Pregnenolone sulfate as a modulator of synaptic plasticity. Psychopharmacology (Berl) 231(17), 3537-3556 (2014).

4. Thiel, G., Müller, I., and Rössler, O.G. Signal transduction via TRPM3 channels in pancreatic β-cells. J. Mol. Endocrinol. 50(3), R75-R83 (2013).

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