A natural steroid hormone
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Pregnenolone

Item No. 19864

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-hydroxy-pregn-5-en-20-one
CAS Number
145-13-1
Synonyms
  • NSC 1616
  • NSC 18158
  • 3β-hydroxy-5-Pregnen-20-one
  • Δ5-Pregnenolone
Molecular Formula
C21H32O2
Formula Weight
316.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 1 mg/mlEthanol: 1 mg/mlMethanol: 1 mg/ml
SMILES
O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O
InChi Code
InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
InChi Key
ORNBQBCIOKFOEO-QGVNFLHTSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $36

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    1 g

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    5 g

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    10 g

    $103

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    Product Description

    Pregnenolone is a natural steroid hormone that serves as a precursor for a wide range of steroids, including mineralocorticoids, glucocorticoids, androgens, and estrogens.1 Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akhtar, M.K., Kelly, S.L., and Kaderbhai, M.A. Cytochrome b5 modulation of 17α hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis. J. Endocrinol. 187(2), 267-274 (2005).

    2. Sedláček, M., Kořínek, M., Petrovič, M., et al. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission. Physiol. Res. 57(Suppl 3), S49-S57 (2008).

    3. Smith, C.C., Gibbs, T.T., and Farb, D.H. Pregnenolone sulfate as a modulator of synaptic plasticity. Psychopharmacology (Berl) 231(17), 3537-3556 (2014).

    4. Thiel, G., Müller, I., and Rössler, O.G. Signal transduction via TRPM3 channels in pancreatic β-cells. J. Mol. Endocrinol. 50(3), R75-R83 (2013).