An IDO1 inhibitor
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Epacadostat

Item No. 19875

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[C(Z)]-4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
CAS Number
1204669-58-8
Synonyms
  • INCB024360
Molecular Formula
C11H13BrFN7O4S
Formula Weight
438.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.16 mg/mlEthanol: 20 mg/ml
λmax
290 nm
SMILES
O/N=C(C1=NON=C1NCCNS(N)(=O)=O)\NC2=CC=C(F)C(Br)=C2
InChi Code
InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16,21H,3-4H2,(H,15,20)(H,17,18)(H2,14,22,23)
InChi Key
FBKMWOJEPMPVTQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

    $236

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    25 mg

    $544

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    Cayman Chemical
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    Product Description

    Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with an IC50 value of 7.1 nM in HeLa cells that demonstrates little activity against the related enzymes IDO2 or tryptophan 2,3-dioxygenase (TDO).1 It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells.1 Epacadostat can also inhibit tumor growth in tumor-bearing mice in a lymphocyte-dependent manner.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1.  .