A selective inhibitor of the Na+/Ca2+ exchanger
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SEA0400

Item No. 19876

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxy-benzenamine
CAS Number
223104-29-8
Molecular Formula
C21H19F2NO3
Formula Weight
371.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 2 mg/mlEthanol: 0.25 mg/ml
λmax
288 nm
SMILES
NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2
InChi Code
InChI=1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3
InChi Key
YSUBLPUJDOWYDP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $250

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    10 mg

    $418

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    50 mg

    $976

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    Product Description

    SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively).1 It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matsuda, T., Arakawa, N., Takuma, K., et al. SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J. Pharmacol. Exp. Ther. 298(1), 249-256 (2001).

    2. Nashida, T., Takuma, K., Fukuda, S., et al. The specific Na+/Ca2+ exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Neurochem.Int. 59(1), 51-58 (2011).

    3. Ago, Y., Kawasaki, T., Nashida, T., et al. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson’s disease. Neuropharmacology 61(8), 1441-1451 (2011).