SEA0400

SEA0400 is a selective inhibitor of the Na⁺/Ca²⁺ exchanger (IC₅₀s = 5, 8.3, and 33 nM for inhibiting Na⁺-dependent Ca²⁺ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively).¹ It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.^2,3

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1. Matsuda, T., Arakawa, N., Takuma, K., et al. SEA0400, a novel and selective inhibitor of the Na⁺-Ca²⁺ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J. Pharmacol. Exp. Ther. 298(1), 249-256 (2001).

2. Nashida, T., Takuma, K., Fukuda, S., et al. The specific Na⁺/Ca²⁺ exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Neurochem.Int. 59(1), 51-58 (2011).

3. Ago, Y., Kawasaki, T., Nashida, T., et al. SEA0400, a specific Na⁺/Ca²⁺ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson’s disease. Neuropharmacology 61(8), 1441-1451 (2011).