An IDH1 inhibitor
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AG-120

Item No. 19894

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-glycinamide
CAS Number
1448347-49-6
Synonyms
  • Ivosidenib
Molecular Formula
C28H22ClF3N6O3
Formula Weight
583.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
246, 307 nm
SMILES
O=C1CC[C@@H](C(N([C@H](C(NC2CC(F)(F)C2)=O)C3=C(Cl)C=CC=C3)C4=CC(F)=CN=C4)=O)N1C5=NC=CC(C#N)=C5
InChi Code
InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1
InChi Key
WIJZXSAJMHAVGX-DHLKQENFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $203

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    25 mg

    $420

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    Product Description

    AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate.1 AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gu, C.-H. Pharmaceutical compositions of therapeutically active compounds. PCT/US2015/020349, 1-13 (2015).