A PRMT5 inhibitor
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HLCL-61 (hydrochloride)

Item No. 19897

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine, monohydrochloride
CAS Number
1158279-20-9
Molecular Formula
C23H24N2O • HCl
Formula Weight
380.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: >1mg/mlEthanol: >1mg/ml
λmax
239, 267, 297 nm
SMILES
COC1=CC=CC=C1CNCC2=CC=C(N(CC)C3=C4C=CC=C3)C4=C2.Cl
InChi Code
InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
InChi Key
XYAVCNMZZKTEGR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

    $354

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    Cayman Chemical
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    Product Description

    HLCL-61 is an inhibitor of protein arginine methyltransferase 5 (PRMT5) that inhibits the growth of multiple acute myeloid leukemia (AML) cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 μM, respectively).1 It is selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an enzyme assay. HLCL-61 induces myeloid differentiation of THP-1 cells and increases CD11b expression in a dose-dependent manner. It also increases expression of miR-29b mRNA resulting in a 4-fold decrease in FLT3 activity in THP-1 cells expressing an FLT3 luciferase reporter.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tarighat, S.S., Santhanam, R., Frankhouser, D., et al. The dual epigenetic role of PRMT5 in acute myeloid leukemia: Gene activation and repression via histone arginine methylation. Leukemia 30(4), 789-799 (2016).