A cell-permeable activator of Wnt signaling
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Wnt Agonist I

Item No. 19903

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine
CAS Number
853220-52-7
Synonyms
  • BML-284
Molecular Formula
C19H18N4O3
Formula Weight
350.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 10 mg/mlEthanol: 0.14 mg/ml
λmax
215, 294 nm
SMILES
COC1=CC=CC(C2=CC(NCC3=CC=C(OCO4)C4=C3)=NC(N)=N2)=C1
InChi Code
InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
InChi Key
FABQUVYDAXWUQP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $132

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    25 mg

    $303

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    50 mg

    $502

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    Product Description

    Wnt Agonist I is a cell-permeable activator of Wnt signaling that does not inhibit GSK3β (IC50 > 60 µM).1 It induces nuclear accumulation of β-catenin, increasing transcriptional activity driven by TCF (EC50 = 700 nM) and altering embryonic development.1,2 Wnt Agonist I is effective in vivo, decreasing tissue damage and improving renal function after ischemia-reperfusion in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J., Wu, X., Mitchell, B., et al. A small-molecule agonist of the Wnt signaling pathway. Agnew. Chem. Int. Ed. Engl. 44(13), 1987-1990 (2005).

    2. Lim, J.C., Kania, K.D., Wijesuriya, H., et al. Activation of β-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J. Neurochem. 106(4), 1855-1865 (2008).

    3. Kuncewitch, M., Yang, W.-L., Corbo, L., et al. WNT agonist decreases tissue damage and improves renal function after ischemia-reperfusion. Shock 43(3), 268-275 (2015).