A PD-1/PD-L1 interaction inhibitor
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PD-1/PD-L1 Inhibitor 1

Item No. 19914

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid
CAS Number
1675201-83-8
Synonyms
  • BMS-1
  • Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 1
Molecular Formula
C29H33NO5
Formula Weight
475.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
211, 236, 270 nm
SMILES
O=C(O)[C@@H]1CCCCN1CC2=C(OC)C=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OC
InChi Code
InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1
InChi Key
ZBOYJODMIAUJHH-SANMLTNESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

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    10 mg

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    25 mg

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    Product Description

    PD-1/PD-L1 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1).1 It inhibits the PD-1/PD-L1 interaction in a time-resolved FRET (TR-FRET) assay (IC50 = 6-100 nM). PD-1/PD-L1 inhibitor 1 reduces LPS-induced increases in PD-1 levels and apoptosis in MH-S mouse alveolar macrophages when used at a concentration of 1 µM.2 Surgical neointimal patching with PD-1/PD-L1-coated patches decreases neointimal thickness and inflammatory cell accumulation in a rat model of patch angioplasty.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chupak, L.S., and Zheng, X. Compounds useful as immunomodulators. PCT/US2014/053695, (2015).

    2. Jia, L., Liu, K., Fei, Q., et al. Programmed cell death-1/programmed cell death-ligand 1 inhibitors exert antiapoptosis and antiinflammatory activity in lipopolysaccharide stimulated murine alveolar macrophages. Exp. Ther. Med. 21(4), 400 (2021).

    3. Bai, H., Wang, Z., Li, M., et al. Inhibition of programmed death-1 decreases neointimal hyperplasia after patch angioplasty. J. Biomed. Mater. Res. 109(2), 269-278 (2020).